Plabcoach
Top 25 High-Yield PLAB 1 / UKMLA-AKT Topics Every…
Preparing for PLAB 1 / UKMLA-AKT requires structured and intelligent preparation. The exam covers a wide range of subjects, but success depends on focusing on high yield, repeatedly tested clinical areas. These topics are directly aligned with the official PLAB/UKMLA blueprint and reflect exam trends observed across real candidate feedback.
Why Focus on High-Yield Topics?
For international medical graduates (IMGs), PLAB is still the exam you sit – but its content and structure are now aligned with the UKMLA.
- The exam prioritizes clinical reasoning over memorization.
- Many questions repeat in themes even if wording changes.
- Emergency management and guidelines are heavily weighted.
- Strong foundation topics improve decision-making across systems.
- Saves time and improves accuracy in SBA-based reasoning.
Cardiovascular Medicine
One of the highest-weight exam subjects.
Key focus areas:
- Acute Coronary Syndrome (STEMI/NSTEMI) management pathway.
- Antiplatelets & anticoagulation indications.
- Arrhythmias: AF, SVT, VT/VF & shockable vs non-shockable rhythms.
- Hypertension guidelines (by ethnicity & age), emergency management.
- Heart Failure: acute vs chronic, BNP interpretation, fluid overload treatment.
- Murmurs, valvular disease basics & common clinical findings.
2. Respiratory Medicine
Exam favourites include:
- Asthma: stepwise therapy and emergency escalation.
- COPD exacerbation: ABG interpretation and oxygen targets (88–92%).
- Pneumonia: CURB-65 scoring and antibiotics.
- Pulmonary Embolism vs pneumonia differentiation.
- Pleural effusion vs pneumothorax vs tension pneumothorax.
3. Gastroenterology
Must know:
- GI bleeding: variceal vs non-variceal management.
- Acute pancreatitis scoring and treatment.
- IBD vs IBS differentiating clues.
- Acute abdomen localisation patterns.
4. Renal Medicine – Nephrology
Critical concepts:
- AKI vs CKD – causes and staging.
- Emergency hyperkalaemia treatment.
- Nephritic vs nephrotic syndrome.
- Renal replacement indications.
- Sodium and potassium disorders.
5. Endocrinology & Diabetes
(Linked into multiple categories inside exam)
High-yield:
- DKA vs HHS pathway; fluid and insulin protocol.
- Hypoglycaemia treatment.
- Thyroid disorders: Graves vs Hashimoto.
- TFT interpretation in pregnancy.
- Thyroid storm and myxoedema coma emergencies.
6. Neurology
Frequently assessed topics:
- Stroke and TIA acute management (thrombolysis window).
- Seizure disorders and status epilepticus treatment.
- Headache red flags and meningitis suspicion.
- Parkinsonism first-line treatment.
- Neuropathy patterns and MS basics.
7. Infectious Diseases
Key scoring areas:
- Sepsis 6 pathway and early recognition of septic shock.
- Bacterial meningitis treatment by age group.
- TB: diagnosis and treatment phases.
- HIV opportunistic infections.
- Malaria and fever in a returning traveller.
8. Emergency Medicine & Toxicology
Core emergency care expected in exam:
- ABCDE trauma assessment.
- Burns management (fluids and percentage calculations).
- Shock types and treatment differentiation.
- Paracetamol overdose treatment timeline.
- Poisoning management (TCA, opioids, alcohol).
9. Haematology / Clinical Hematology
- Anaemia: microcytic, normocytic, and macrocytic approaches.
- Haemolysis labs and reticulocyte interpretation.
- Anticoagulation and warfarin reversal, INR management.
- Blood transfusion reactions.
10. Pharmacology
Very common SBA reasoning area
- Prescribing safety and drug interactions.
- Top drug toxicities (lithium, digoxin, methotrexate).
- Drug use in pregnancy and breastfeeding.
12. Dermatology
Image-based, pattern recognition style.
Learn:
- Meningococcal rash emergency recognition.
- Eczema vs psoriasis management.
- SJS/TEN vs erythema multiforme.
- Cellulitis vs necrotizing fasciitis.
13. Trauma & Orthopaedics
Apply emergency thinking
- Hip fracture pathways.
- Compartment syndrome red flags.
- Cauda equina syndrome.
- Joint infection vs gout vs pseudogout.
14. Paediatrics
Key high-yield areas:
- Bronchiolitis and croup treatment.
- Neonatal jaundice.
- Febrile seizures.
- Safeguarding red flag spotting.
15. Women Health (Obstetrics & Gynaecology)
Common questions include:
- Ectopic pregnancy diagnosis and β-hCG interpretation.
- Types of miscarriage.
- Pre-eclampsia / eclampsia and magnesium sulphate management.
- Post-partum haemorrhage management.
- Contraception choices based on medical risk.
16. Mental Health
Focus on real-life scenarios
- Suicide assessment and risk stratification.
- Depression and anxiety management.
- Delirium vs dementia recognition.
- Antipsychotic side-effect profiles.
- Capacity assessment using MCA principles.
17. Ethical & Legal Issues
High scoring & often “easy marks.”
Understand deeply:
- Consent, competence, and capacity.
- Confidentiality and safeguarding rules.
- Duty of candour.
- End-of-life decision making.
18. Epidemiology & Statistics
Exam heavy topic:
- Sensitivity, specificity, PPV, and NPV.
- Study designs.
- Screening principles.
- Bias types.
- Statistical interpretation.
19. Oncology / Palliative Care
Important topics:
- Red-flag cancer symptom pathways.
- Oncologic emergencies (SVC obstruction).
- Pain ladder and end-of-life care.
20. Sexual Health
Regularly tested
- STI diagnosis and partner notification.
- PID and ectopic concern.
- HIV treatment basics.
21. ENT
Emergencies are key:
- Epistaxis management.
- Peritonsillar abscess.
- Sudden hearing loss.
- Airway obstruction emergencies.
22. Ophthalmology
(Part of emergency triage in many mocks)
- Acute angle-closure glaucoma.
- Red eye causes.
- CRAO vs retinal detachment.
23. Urology
- Testicular torsion emergency.
- Urinary retention and catheterisation.
- Renal stones presentations.
24. Radiology
- X-ray basics for trauma.
- CT head selection.
- Chest X-ray interpretation.
25. Clinical Anatomy
- Applied anatomy relevant to injuries & nerve damage patterns.
How to Study These Topics Efficiently
If you strip away the noise, here’s the simple, practical summary:
- Use SBAs to learn concepts.
- Take full SmartMock tests.
- Use SmartNotes for fast revision.
- Focus on clinical reasoning, not just facts.
- Track mistakes and revise patterns.
Conclusion
Mastering these high-yield topics aligned with UKMLA PLAB blueprint categories builds confidence, improves accuracy, and significantly boosts exam scores.