Top 25 High-Yield PLAB 1 / UKMLA-AKT Topics Every Candidate Must Master – 2025 Ultimate Study Guide

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Top 25 High-Yield PLAB 1 / UKMLA-AKT Topics Every…

Top 25 High-Yield PLAB 1 / UKMLA-AKT Topics Every Candidate Must Master – 2025 Ultimate Study Guide

Home » Top 25 High-Yield PLAB 1 / UKMLA-AKT Topics Every Candidate Must Master – 2025 Ultimate Study Guide

Preparing for PLAB 1 / UKMLA-AKT requires structured and intelligent preparation. The exam covers a wide range of subjects, but success depends on focusing on high yield, repeatedly tested clinical areas. These topics are directly aligned with the official PLAB/UKMLA blueprint and reflect exam trends observed across real candidate feedback.

Why Focus on High-Yield Topics?

For international medical graduates (IMGs), PLAB is still the exam you sit – but its content and structure are now aligned with the UKMLA.

  • The exam prioritizes clinical reasoning over memorization.
  • Many questions repeat in themes even if wording changes.
  • Emergency management and guidelines are heavily weighted.
  • Strong foundation topics improve decision-making across systems.
  • Saves time and improves accuracy in SBA-based reasoning.

Cardiovascular Medicine

One of the highest-weight exam subjects.
Key focus areas:

  • Acute Coronary Syndrome (STEMI/NSTEMI) management pathway.
  • Antiplatelets & anticoagulation indications.
  • Arrhythmias: AF, SVT, VT/VF & shockable vs non-shockable rhythms.
  • Hypertension guidelines (by ethnicity & age), emergency management.
  • Heart Failure: acute vs chronic, BNP interpretation, fluid overload treatment.
  • Murmurs, valvular disease basics & common clinical findings.

2. Respiratory Medicine

Exam favourites include:

  • Asthma: stepwise therapy and emergency escalation.
  • COPD exacerbation: ABG interpretation and oxygen targets (88–92%).
  • Pneumonia: CURB-65 scoring and antibiotics.
  • Pulmonary Embolism vs pneumonia differentiation.
  • Pleural effusion vs pneumothorax vs tension pneumothorax.

3. Gastroenterology

Always high scoring due to emergencies.
Must know:

  • GI bleeding: variceal vs non-variceal management.
  • Acute pancreatitis scoring and treatment.
  • IBD vs IBS differentiating clues.
  • Acute abdomen localisation patterns.

4. Renal Medicine – Nephrology

Critical concepts:

  • AKI vs CKD – causes and staging.
  • Emergency hyperkalaemia treatment.
  • Nephritic vs nephrotic syndrome.
  • Renal replacement indications.
  • Sodium and potassium disorders.

5. Endocrinology & Diabetes

(Linked into multiple categories inside exam)
High-yield:

  • DKA vs HHS pathway; fluid and insulin protocol.
  • Hypoglycaemia treatment.
  • Thyroid disorders: Graves vs Hashimoto.
  • TFT interpretation in pregnancy.
  • Thyroid storm and myxoedema coma emergencies.

6. Neurology

Frequently assessed topics:

  • Stroke and TIA acute management (thrombolysis window).
  • Seizure disorders and status epilepticus treatment.
  • Headache red flags and meningitis suspicion.
  • Parkinsonism first-line treatment.
  • Neuropathy patterns and MS basics.

7. Infectious Diseases

Key scoring areas:

  • Sepsis 6 pathway and early recognition of septic shock.
  • Bacterial meningitis treatment by age group.
  • TB: diagnosis and treatment phases.
  • HIV opportunistic infections.
  • Malaria and fever in a returning traveller.

8. Emergency Medicine & Toxicology

Core emergency care expected in exam:

  • ABCDE trauma assessment.
  • Burns management (fluids and percentage calculations).
  • Shock types and treatment differentiation.
  • Paracetamol overdose treatment timeline.
  • Poisoning management (TCA, opioids, alcohol).

9. Haematology / Clinical Hematology

  • Anaemia: microcytic, normocytic, and macrocytic approaches.
  • Haemolysis labs and reticulocyte interpretation.
  • Anticoagulation and warfarin reversal, INR management.
  • Blood transfusion reactions.

10. Pharmacology

Very common SBA reasoning area

  • Prescribing safety and drug interactions.
  • Top drug toxicities (lithium, digoxin, methotrexate).
  • Drug use in pregnancy and breastfeeding.

12. Dermatology

Image-based, pattern recognition style.
Learn:

  • Meningococcal rash emergency recognition.
  • Eczema vs psoriasis management.
  • SJS/TEN vs erythema multiforme.
  • Cellulitis vs necrotizing fasciitis.

13. Trauma & Orthopaedics

Apply emergency thinking

  • Hip fracture pathways.
  • Compartment syndrome red flags.
  • Cauda equina syndrome.
  • Joint infection vs gout vs pseudogout.

14. Paediatrics

Key high-yield areas:

  • Bronchiolitis and croup treatment.
  • Neonatal jaundice.
  • Febrile seizures.
  • Safeguarding red flag spotting.

15. Women Health (Obstetrics & Gynaecology)

Common questions include:

  • Ectopic pregnancy diagnosis and β-hCG interpretation.
  • Types of miscarriage.
  • Pre-eclampsia / eclampsia and magnesium sulphate management.
  • Post-partum haemorrhage management.
  • Contraception choices based on medical risk.

16. Mental Health

Focus on real-life scenarios

  • Suicide assessment and risk stratification.
  • Depression and anxiety management.
  • Delirium vs dementia recognition.
  • Antipsychotic side-effect profiles.
  • Capacity assessment using MCA principles.

17. Ethical & Legal Issues

High scoring & often “easy marks.”
Understand deeply:

  • Consent, competence, and capacity.
  • Confidentiality and safeguarding rules.
  • Duty of candour.
  • End-of-life decision making.

18. Epidemiology & Statistics

Exam heavy topic:

  • Sensitivity, specificity, PPV, and NPV.
  • Study designs.
  • Screening principles.
  • Bias types.
  • Statistical interpretation.

19. Oncology / Palliative Care

Important topics:

  • Red-flag cancer symptom pathways.
  • Oncologic emergencies (SVC obstruction).
  • Pain ladder and end-of-life care.

20. Sexual Health

Regularly tested

  • STI diagnosis and partner notification.
  • PID and ectopic concern.
  • HIV treatment basics.

21. ENT

Emergencies are key:

  • Epistaxis management.
  • Peritonsillar abscess.
  • Sudden hearing loss.
  • Airway obstruction emergencies.

22. Ophthalmology

(Part of emergency triage in many mocks)

  • Acute angle-closure glaucoma.
  • Red eye causes.
  • CRAO vs retinal detachment.

23. Urology

  • Testicular torsion emergency.
  • Urinary retention and catheterisation.
  • Renal stones presentations.

24. Radiology

  • X-ray basics for trauma.
  • CT head selection.
  • Chest X-ray interpretation.

25. Clinical Anatomy

  • Applied anatomy relevant to injuries & nerve damage patterns.

How to Study These Topics Efficiently

If you strip away the noise, here’s the simple, practical summary:

  • Use SBAs to learn concepts.
  • Take full SmartMock tests.
  • Use SmartNotes for fast revision.
  • Focus on clinical reasoning, not just facts.
  • Track mistakes and revise patterns.

Conclusion

Mastering these high-yield topics aligned with UKMLA PLAB blueprint categories builds confidence, improves accuracy, and significantly boosts exam scores.

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